Gene Frequencies of the Human Platelet Antigen-3in Different Populations
نویسندگان
چکیده
منابع مشابه
Human platelet antigen polymorphism in bronchial asthma
Background: Asthma is recognized as a common cause of disability, of great economic cost, and of preventable deaths. In this study we aimed to test our hypothesis to evaluate the relationship between the Human Platelet Antigen-1(HPA-1) polymorphism and bronchial asthma and its severity, which would suggest genetic variances that may be responsible for expression or activation of these receptors...
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The effects of the various evolutionary factors-mutation, cross breeding,. selection and inbreeding-can be reduced to common terms by considering the rates of change which they tend to bring about in the relative frequencies of alleles.' In the absence of such factors, there is constancy of gene frequencies from the symmetry of the Mendelian mechanism. The frequency (q) of a given gene changes ...
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Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences ...
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The only member of human cytochrome P450 E subfamily is CYP2E1 (Zhuge et al., 2003), located in the 10q24.3-qter region of chromosome 10. It contains 9 exons, 8 introns, and a typical TATA box and it spans 11,413 base pairs of genomic DNA (Umeno, 1988). CYP2E1 plays a key role in the metabolic activation of many low molecular weight carcinogens (e.g., benzene, N-nitrosamines, carbon tetrachlori...
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ژورنال
عنوان ژورنال: Clinical and Applied Thrombosis/Hemostasis
سال: 2005
ISSN: 1076-0296,1938-2723
DOI: 10.1177/107602960501100111